Periconceptional nutrient intakes and risks of conotruncal heart defects
نویسندگان
چکیده
منابع مشابه
One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects.
BACKGROUND Evidence exists for an association between use of vitamin supplements with folic acid in early pregnancy and reduced risk for offspring with conotruncal heart defects. A few observations have been made about nutrients related to one-carbon metabolism other than folate. Our prospective study attempted to extend information on nutrition and conotruncal heart defects by measuring analyt...
متن کاملConotruncal Heart Defects: Altered Tissue Morphology and Hemodynamics
1 Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, SC 29208, USA 2 Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA 3 Department of Pediatrics (Neonatology), Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, NC 297710, USA 4 Department of Cell...
متن کاملGenetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects.
How folate reduces the risks of congenital anomalies is unknown. The authors focused on a gene involved in folate transport-reduced folate carrier-1 gene (RFC1). Using data from a California case-control study (1987-1989 births), the authors investigated whether the risks of orofacial clefts or conotruncal heart defects were influenced by a polymorphism of infant RFC1 or by an interaction betwe...
متن کاملGene-Gene Interactions in the Folate Metabolic Pathway and the Risk of Conotruncal Heart Defects
Conotruncal and related heart defects (CTRD) are common, complex malformations. Although there are few established risk factors, there is evidence that genetic variation in the folate metabolic pathway influences CTRD risk. This study was undertaken to assess the association between inherited (i.e., case) and maternal gene-gene interactions in this pathway and the risk of CTRD. Case-parent tria...
متن کاملNeural tube defects and periconceptional folic acid.
T he cause of neural tube defects (NTDs) is multi-factorial. The possibility that folic acid played a role was first reported in 1964. 1 Several clinical trials subsequently showed that the risk of recurrence and first occurrence of these abnormalities was decreased by peri-conceptional folic acid supplementation, 2–5 On the basis of these findings, supplementation of 400 µg folic acid was reco...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2010
ISSN: 1542-0752,1542-0760
DOI: 10.1002/bdra.20648